Eiki Takimoto and David A. Kass Role of Oxidative Stress in Cardiac Hypertrophy and Remodeling

Role of oxidative stress in cardiac hypertrophy and remodeling.

Cardiac adaptation in response to intrinsic or external stress involves a complex process of chamber remodeling and myocyte molecular modifications. A fundamental response to increased biomechanical stress is cardiomyocyte and chamber hypertrophy. Although this may provide initial salutary compensation to the stress, sustained hypertrophic stimulation becomes maladaptive, worsening morbidity an...

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.

BACKGROUND Sustained pressure overload induces pathological cardiac hypertrophy and dysfunction. Oxidative stress linked to nitric oxide synthase (NOS) uncoupling may play an important role. We tested whether tetrahydrobiopterin (BH4) can recouple NOS and reverse preestablished advanced hypertrophy, fibrosis, and dysfunction. METHODS AND RESULTS C57/Bl6 mice underwent transverse aortic constr...

Protein kinase G I alpha activates an anti-remodeling signaling pathway in the heart via an interaction with the MAPKKK mixed lineage kinase 3

Background cGMP signaling inhibits pathologic cardiac hypertrophy and remodeling in vivo. In prior studies, we explored the role of the cGMP-dependent protein kinase I alpha (PKGIa) in regulating cardiac remodeling by studying mice with mutations in the PKGIa leucine zipper (LZ) domain [1], in which PKGIa kinase activity is retained but LZ-mediated protein-protein interactions are abolished. Th...

Role of oxidative stress in the aortic constriction-induced ventricular hypertrophy in rat

Introduction:Severe abdominal aortic constriction above the renal arteries induces arterial hypertension above the stenotic site that is the cause of cardiac hypertrophy. Previous studies have shown that high blood pressure induces myocardial oxidative stress with conflicting results. In the present study, we assessed the effects of acute hypertension on the myocardial oxidative stress an...

Sustained Soluble Guanylate Cyclase Stimulation offsets NOS Inhibition to Restore Acute Cardiac Modulation by Sildenafil